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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Dr Charlie Wilson

Position: LabEx Cortex Fellow

Company: Inserm U1208

Mailing Address:
18, avenue Doyen Jean Lépine

69675 - Bron Cedex - France
External Link:
Phone: +33 4 72 91 34 56
Fax: @crewilson

Neurobiology of executive functions - Teams

Research interest

I study how the brain produces the sophisticated forms of cognition that allow humans and macaques to achieve goals flexibly and efficiently. We use these capacities to adapt to and profit from our environment. My specific work focuses on the mechanisms at work in the prefrontal cortex, the anterior part of cortex particularly developed in primate species. I study the ways in which different cortical regions interact with prefrontal cortex to produce flexible and efficient behaviour. To do this we make recordings of neural activity in different phases of a cognitive task, in order to link the activity to the task.

Currently at SBRI I study whether and how cortical oscillations are implicated in these processes. Cortical oscillations are increasing thought to subserve interaction at different levels between assemblies in the brain.

I currently work on two major projects. In the first we seek to understand how these oscillations and other neurophysiological markers change during the early stages of Parkinson's disease prior to the development of the classical symptoms of the disease. This project has clear clinical benefits in terms of understanding early neurodegenration, but also brings fundamental knowledge about the assemblies of the frontal cortex and their relation to dopamine.

In the second project, we are studying the way in which cortical assemblies interact in order to subserve 'learning to learn', the principle of improving one's learning, becoming flexible in one's learning, and applying task sets appropriate to a given situation. We will study the very specific interactions of the anterior cingulate cortex with prefrontal cortex, and how these interactions are mediated by different neurotransmitter systems.'

Procyk, E., Wilson C.R.E., Stoll, F.M., Faraut M.C.M., Petrides M., Amiez C. (2016) Midcingulate motor map and feedback detection: converging data from humans and monkeys. Cerebral Cortex, 26: 467-476 download
Stoll* F., Wilson* C.R.E., Faraut M.C.M., Vezoli J., Knoblauch K., Procyk E. (2016) The effects of cognitive control and time on beta oscillations. Cerebral Cortex, 26: 1715-1732
Wilson CRE; Vezoli J; Stoll FM; Faraut MCM; Leviel V; Knoblauch K; Procyk E. (2016) Prefrontal Markers and Cognitive Performance Are Dissociated during Progressive Dopamine Lesion PLoS Biol 14(11): e1002576. download
Faraut M.C., Procyk E., Wilson C.R.E. (2016) Learning to learn about uncertain feedback. Learning and Memory, 23: 90-98.
Amiez C, Champod AS, Wilson CR, Procyk E, Petrides M (2015) A unilateral medial frontal cortical lesion impairs trial and error learning without visual control Neuropsychologia. 2015 Aug;75:314-21
Vezoli J, Wianny F, Dzahini K, Dolmazon V, Bernat A, Fifel K, Wilson CRE, Gronfier C, Procyk E, Cooper HM, Savatier P, Dehay C, Kennedy H (2014) Host-integration of neural precursors in parkinsonian monkeys: outcome on clinical, cognitive, circadian and DA function. Cell Symposia: Translational Neuroscience. Arlington, VA, USA. download
Vezoli J, Dzahini K, Costes N, Wilson CR, Fifel K, Cooper HM, Kennedy H, Procyk E (2014) Increased DAT binding in the early stage of the dopaminergic lesion: a longitudinal [11C]PE2I binding study in the MPTP-monkey. Neuroimage 102:249-261
O’Reilly J.X.*, Croxson P.L.*, Jbabdi S., Sallet J., Noonan M.P., Mars R.B., Browning P.G., Wilson C.R.E., Mitchell A.S., Miller K.L., Rushworth M.F.S., Baxter M.G. (2013) Causal relationship between anatomical and functional connectivity: Evidence from fMRI in rhesus monkeys before and after corpus callosum transection. PNAS 110(34): 13982-7.
Khamassi M, Wilson C, Rothé R, Quilodran R, Dominey PF, Procyk E (2011) Meta-learning, cognitive control, and physiological interactions between medial and lateral prefrontal cortex. Neural Basis of Motivational and Cognitive Control, MIT Press, publisher.
Wilson CRE, Gaffan D, Browning PGF, Baxter MG. (2010) Functional localization within prefrontal cortex: Missing the forest for the trees? Trends in Neurosciences 33(12): 533-540 download
Wilson CRE, Buckley MJ, Gaffan D (2010) Degraded transfer of memories between the visual hemifields in normal Macaques. Neuropsychologia. 48(5): 1376-1384 download
Gaffan D, Wilson CRE (2008) Medial temporal and prefrontal function: recent behavioural disconnection studies in the macaque monkey. Cortex 44(8): 928-35 download
Mitchell AS, Browning PGF, Wilson CRE, Baxter MG, Gaffan D. (2008) Dissociable roles for cortical and subcortical structures in memory retrieval and acquisition. Journal of Neuroscience 28(34): 8387-96 download
Wilson CRE, Gaffan D (2008) Prefrontal-inferotemporal interaction is not always necessary for reversal learning Journal of Neuroscience 28(21):5529-38 download
Buckley MJ, Wilson CRE, Gaffan D (2008) Fornix transection impairs visuospatial memory acquisition more than retrieval. Behavioral Neuroscience, 122(1):44-53 download
Wilson CRE, Baxter MG, Easton A, Gaffan D (2008) Addition of fornix transection to frontal-temporal disconnection increases the impairment in object-in-place memory in macaque monkeys. European Journal of Neuroscience 27(7): 1814-1822 download
Wilson CRE, Gaffan D, Mitchell AS, Baxter MG (2007) Neurotoxic lesions of ventrolateral prefrontal cortex impair object-in-place scene memory. European Journal of Neuroscience, 25(8):2514-22 download
Wilson CRE, Charles D, Buckley MJ, Gaffan D (2007) Fornix transection impairs learning of randomly changing object discriminations. Journal of Neuroscience, 27(47): 12868-73 download