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Stem-cell and Brain Research Institute
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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Camille Lamy

Position: Research Engineer

Company: Inserm u846

Mailing Address:
18 avenue du Doyen Jean LÚpine

69675 - Bron Cedex - France
External Link: www.sbri.fr
E-mail: Camille.Lamy@inserm.fr

Cortical architecture, coding and perception - Teams

Research interest

A major part of my work in the team concerns the development of a so called frameless stereotaxy or neuronavigation system, the “Brainsight Primate”. This system makes it possible to perform very precise intracerebral injections of neuronal tracers or place probes, electrodes etc. in buried cortex.

Instead of a stereotactic frame, this 3D coordinate system is based on anatomical images obtained in MRI. A position sensor is used in the surgical suite to monitor the location and orientation of tools then, software is used to map these locations to the pre-operative image space. The first step of the processus consists in implanting markers (the position sensors) on the skull of the animal. These markers are identified by the Brainsight system and the software yields a series of coordinates in image space. The software uses these markers to calculate the 3D coordinates of individual voxels. Then we define our target and perform the surgery. We use a pointer recognized by infrared camera, which allows us to define the optimal pathway to the target.

I have used traditional stereotaxy in the past and I find this system is very powerful. It allows us more freedom in deciding the target and the path to target than with traditional stereotaxy.

After the injection of neuronal tracers, I take part in detection and counting of fluorescent-labelled cells, histological staining and immuno-histochimical reaction. An important part of the processing is segmentation: we determine according to histological staining the areal and laminar distribution of labelled cells.

In collaboration with “Explora Nova”, we are developing 3D reconstruction of the brain in order to accurately measure pathlengths.

Markov NT, Ercsey-Ravasz MM, Ribeiro Gomes AR, Lamy C, Magrou L, Vezoli J, Misery P, Falchier A, Quilodran R, Gariel MA, Sallet J, Gamanut R, Huissoud C, Clavagnier S, Giroud P, Sappey-Marinier D, Barone P et al (2014) A weighted and directed interareal connectivity matrix for macaque cerebral cortex. Cereb Cortex, 2014, 24(1):17-36 download
Markov NT, Vezoli J, Chameau P, Falchier A, Quilodran R, Huissoud C, Lamy C, Misery P, Giroud P, Ullman S, Barone P, Dehay C, Knoblauch K, Kennedy H. (2014) The anatomy of hierarchy: Feedforward and feedback pathways in macaque visual cortex. J Comp Neurol, 2014, 522(1):225-259 download
Markov N.T., Ercsey-Ravasz M., Lamy C., Ribeiro-Gomes A.R., Magrou L., Misery P., Giroud P. Barone P., Dehay C., Toroczkai Z., Knoblauch, K., Van Essen D.C., Kennedy H. (2013) The role of long-range connections on the specificity of the macaque interareal cortical network. Proc Nat Acad Sci USA, 2013, 110, 5187-5192 download
Ercsey-Ravasz M, Markov NT, Lamy C, Van Essen DC, Knoblauch K, Toroczkai Z, Kennedy H (2013) A Predictive Network Model of Cerebral Cortical Connectivity Based on a Distance Rule. Neuron 80:184-197 download
Markov NT, Misery P, Falchier A, Lamy C, Vezoli J, Quilodran R, Gariel MA, Giroud P, Ercsey-Ravasz M, Pilaz LJ, Huissoud C, Barone P, Dehay C, Toroczkai Z, Van Essen DC, Kennedy H, Knoblauch K (2011) Weight Consistency Specifies Regularities of Macaque Cortical Networks. Cereb Cortex. 2011, 21:1254-1272 download