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Conference by Adrien Meguerditchian

Published on March 28, 2017

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Bertrand Pain


Company: U1208, INSERM, USC1361, INRA

Mailing Address:
18, avenue Doyen Jean Lépine

69675 - Bron Cedex - France
External Link:

Physiology and biotechnology of avian stem cells - Teams (leader)

Research interest

Interest in investigating the ES cells physiology. Our research group aims to understand the molecular mechanisms that control pluripotency, somatic and germinal differentiation using the chicken as a non mammalian model system.

Interest in compairing stem and germ cell physiology in different avian and mammalian species of agronomical interest.

Interest in developing new cell lines from various species as substrates for viral vaccine replication.

Kress C, Montillet G, Jean C, Fuet A, Pain B (2016) Chicken embryonic stem cells and primordial germ cells display different heterochromatic histone marks than their mammalian counterparts 2016 Feb 10;9:5. doi: 10.1186/s13072-016-0056-6
Bachelard E, Raucci F, Montillet G, Pain B (2015) Identification of side population cells in chicken embryonic gonads Theriogenology. 2015 Feb;83(3):377-84
Raucci F, Fuet A, Pain B (2015) In vitro generation and characterization of chicken long-term germ cells from different embryonic origins Theriogenology. 2015 Sep 15;84(5):732-742.e2
Chen H, Aksoy I, Gonnot F, Osteil P, Aubry M, Hamela C, Rognard C, Hochard A, Voisin S, Fontaine E, Mure M, Afanassieff M, Cleroux E, Guibert S, Chen J, Vallot C, Acloque H, Genthon C, Donnadieu C, De Vos J, Sanlaville D, Guérin JF, Weber M, Stanton LW, R (2015) Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency Nat Commun. 2015 May 13;6:7095
Couteaudier M, Trapp-Fragnet L, Auger N, Courvoisier K, Pain B, Denesvre C, Vautherot JF (2015) Derivation of keratinocytes from chicken embryonic stem cells: establishment and characterization of differentiated proliferative cell populations Stem Cell Res. 2015 Mar;14(2):224-37
Jean C, Oliveira NM, Intarapat S, Fuet A, Mazoyer C, De Almeida I, Trevers K, Boast S, Aubel P, Bertocchini F, Stern CD, Pain B (2015) Transcriptome analysis of chicken ES, blastodermal and germ cells reveals that chick ES cells are equivalent to mouse ES cells rather than EpiSC Stem Cell Res. 2015 Jan;14(1):54-67
Jean C, Aubel P, Soleihavoup C, Bouhallier F, Voisin S, Lavial F, Pain B (2013) Pluripotent genes in avian stem cells Developmental growth and differentiation 25(1): 41-51
Fresard L, Morisson M, Brun JM, Collin A, Pain B, Minvielle F, Pitel F (2013) Epigenetics and phenotypic variability: some interesting insights from birds. Genet Sel Evol 45:16
Guibert E, Prieur B, Cariou R, Courant F, Antignac JP, Pain B, Brillard JP, Froment P (2013) Effects of mono-(2-ethylhexyl) phthalate (MEHP) on chicken germ cells cultured in vitro. Environ Sci Pollut Res Int, 20:2771-2783
Acloque H, Lavial F, Pain B (2012) Astacin-like metallo-endopeptidase is dynamically expressed in embryonic stem cells and embryonic epithelium during morphogenesis. Dev Dyn 241:574-582
Theunissen TW, Costa Y, Radzisheuskaya A, van Oosten AL, Lavial F, Pain B, Castro LF, Silva JC (2011) Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development 138:4853-4865
Bouhallier F, Allioli N, Lavial F, Chalmel F, Perrard MH, Durand P, Samarut J, Pain B, Rouault JP. (2010) Role of miR-34c microRNA in the late steps of spermatogenesis. RNA. 16(4): 720-31 download
Lavial F, Pain B (2010) Chicken embryonic stem cells as a non-mammalian embryonic stem cell model Dev Growth Differ. 52(1): 101-14 download
Lavial F, Acloque H, Bachelard E, Nieto MA, Samarut J, Pain B. (2009) Ectopic expression of Cvh (Chicken Vasa homologue) mediates the reprogramming of chicken embryonic stem cells to a germ cell fate. Dev Biol. 330(1): 73-82. download
Lavial F, Acloque H, Bertocchini F, Macleod DJ, Boast S, Bachelard E, Montillet G, Thenot S, Sang HM, Stern CD, Samarut J, Pain B (2007) The Oct4 homologue PouV and Nanog regulate pluripotency in chicken embryonic stem cells. Dev 134(19):3549-3563 download