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SBRI is in "Le Monde"

Published on January 31, 2012



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Annick Elisabeth Lefèvre

Position: Researcher

Company: Inserm u846


Mailing Address:
Laboratoire de Biologie de la Reproduction, Faculté de Médecine
8 Avenue Rockefeller
69373 - Lyon Cedex 08 - France
External Link:
E-mail: annick.lefevre@inserm.fr
Phone: 04 78 77 71 89
Fax: 04 78 01 49 75


Group(s):
Reproduction, epigenesis and development - Teams (leader)

Research interest

Genomic imprinting in oocytes and stem cells

Publications
Al-Khtib M, Perret A, Khoueiry R, Ibala-Romdhane S, Blachère T, Greze C, Lornage J, Lefèvre A (2011) Vitrification at the germinal vesicle stage does not affect the methylation profile of H19 and KCNQ1OT1 imprinting centers in human oocytes subsequently matured in vitro Fertility and sterility 95(6): 1955-60 download
Borghol N, Blachere T, Lefevre A. (2008) Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatids injection into mouse oocytes Genomics 91 (5): 415-422 download
Khoureiry R, Ibala-Rhomdane S, Mery L, Blachere T, Guerin JF, Lornage J, Lefevre A. (2008) Dynamic CpG methylation of the KCNQ1OT1 gene during maturation of human oocytes J Med Genet 45 (9): 583-8 download
Mery L, Lefevre A, Benchaib M, Demirci B, Salle B, Guerin JF, Lornage J. (2007) Follicular growth in vitro: detection of growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15) during in vitro culture of ovine cortical slices Mol Reprod Dev 74(6): 767-74 download
Borghol, N. Lornage, J. Blachere, T. Sophie Garret, A. Lefevre, A. (2006) Epigenetic status of the H19 locus in human oocytes following in vitro maturation Genomics 87 (3): 417 - 426 download
Ziyyat A, Lefevre A (2001) Differential gene expression in pre-implantation embryos from mouse oocytes injected with round spermatids or spermatozoa Hum Reprod 16 (7): 1449-56 download
Hammami-Hamza S, Doussau M, Bernard J, Rogier E, Duquenne C, Richard Y, Lefevre A, Finaz C (2001) Cloning and sequencing of SOB3, a human gene coding for a sperm protein homologous to an antimicrobial protein and potentially involved in zona pellucida binding Mol Hum Reprod 7(7): 625-32 download
Ziyyat A, Lassalle B, Testart J, Briot P, Amar E, Finaz C, Lefevre A. (1999) Flow cytometry isolation and reverse transcriptase-polymerase chain reaction characterization of human round spermatids in infertile patients Hum Reprod 14(2): 379-87 download
Lefevre A, Duquenne C, Rousseau-Merck MF, Rogier E, Finaz C. (1999) Cloning and characterization of SOB1, a new testis-specific cDNA encoding a human sperm protein probably involved in oocyte recognition Biochem Biophys Res Comm 259(1): 60-6 download
Lassalle B, Ziyyat A, Testart J, Finaz C, Lefevre A. (1999) Flow cytometric method to isolate round spermatids from mouse testis Hum Reprod 14(2): 388-94 download
Martin Ruiz C, Duquenne C, Treton D, Lefevre A, Finaz C. (1998) SOB3, a human sperm protein involved in zona pellucida binding: physiological and biochemical analysis, purification Mol Reprod Dev 49(3): 286-97 download
Finaz C, Lefevre A. (1998) Gamete recognition in mammals: sperm and zona pellucida interactions Contracept Fertil Sex 26(7-8): 542-8
Lefevre A, Martin Ruiz C, Chokomian S, Duquenne C, Finaz C. (1997) Characterization and isolation of SOB2, a human sperm protein with a potential role in oocyte membrane binding Mol Hum Reprod 3(6): 507-16 download
Boue F, Duquenne C, Lassalle B, Lefevre A, Finaz C. (1995) FLB1, a human protein of epididymal origin that is involved in the sperm-oocyte recognition process Biol Reprod 52(2): 267-78 download
Astraudo C, Lefevre A, Boue F, Durr F, Finaz C. (1995) In vivo regulation of rat epididymal proteins by retinoids: analysis by two-dimensional electrophoresis Arch Androl 35(3): 247-59
Machelon V, Emilie D, Lefevre A, Nome F, Durand-Gasselin I, Testart J. (1994) Interleukin-6 biosynthesis in human preovulatory follicles: some of its potential roles at ovulation J Clin Endocrinol Metab 79(2): 633-42 download
Lefevre A, Rogier E, Astraudo C, Duquenne C, Finaz C. (1994) Regulation by retinoids of luteinizing hormone/chorionic gonadotropin receptor, cholesterol side-chain cleavage cytochrome P-450, 3 beta-hydroxysteroid dehydrogenase/delta (5-4)-isomerase and 17 alpha-hydroxylase/C17-20 lyase cytochrome P-450 messenger ri Mol Cell Endocrinol 106(1-2): 31-9
Boue F, Lassalle B, Duquenne C, Villaroya S, Testart J, Lefevre A, Finaz C. (1992) Human sperm proteins from testicular and epididymal origin that participate in fertilization: modulation of sperm binding to zona-free hamster oocytes, using monoclonal antibodies Mol Reprod Dev 33(4): 470-80
Lefevre A, Astraudo C, Finaz C. (1991) Inhibition of luteinizing hormone-human chorionic gonadotropin binding by retinoids in a Leydig cell line Mol Cell Endocrinol 76(3): 115-23
Finaz C, Boue F, Meduri G, Lefevre A. (1991) Characterization of rat epithelial epididymal cells purified on a discontinuous Percoll gradient J Reprod Fertil 91(2): 617-25
Lefevre A, Vigier M, Guillaumot P, Finaz C. (1988) Steroidogenesis expression depends on negative control(s): analysis in Leydig X adrenal intraspecific cell hybrids Mol Cell Endocrinol 60(2-3): 169-76
Finaz C, Lefevre A, Dampfhoffer D. (1987) Construction of a Leydig cell line synthesizing testosterone under gonadotropin stimulation: a complex endocrine function immortalized by cell hybridization Proc Natl Acad Sci U S A 84(16): 5750-3 download
Lefevre A, Finaz C. (1986) Systematic shut-off of the hormone receptors in intraspecific adrenal x Leydig cell hybrids Exp Cell Res 162(1): 261-7
Lefevre A, Finaz C, Berthelon MC, Saez JM. (1985) Modulation of cultured mouse Leydig cells adenylate cyclase by forskolin and hCG Mol Cell Endocrinol 40(2-3): 107-14
Finaz C, Lefevre A, Teissié J. (1984) Electrofusion. A new, highly efficient technique for generating somatic cell hybrids Exp Cell Res 150(2): 477-82
Lefevre A, Saez JM, Finaz C. (1983) hCG responsiveness of purified Leydig cells from immature and mature rats Horm Res 17(2): 114-20
Lefevre A, Faucon-Biguet N, Mathieu D, Tournier P, Saez JM. (1981) Modification of steroidogenesis in a mouse adrenal cell line (Y-1) transformed by simian adenovirus SA-7 Steroids 31(3): 315-25
Lefevre A, Morera AM, Saez JM. (1978) Adrenal cholesterol-binding protein: properties and partial purification FEBS Lett 89(2): 287-92
Lefevre A, Saez JM. (1977) Demonstration of a cytosol protein binding cholesterol in the adrenal glands C R Acad Sci Hebd Seances Acad Sci D 284(7): 561-4



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